2026
Mohr, T., Schiffer, M., Ramanujam, D., Carls, E., Zgierski-Johnston, C.M., Kok, T., Niemann, P., Geisen, C., Kohl, P., Engelhardt, S., Fleischmann, B.K. and Roell, W.
J Physiol, 604: 1708-1735.
2025
Polyglutamylation of microtubules drives neuronal remodeling
Antoneta Gavoci, Anxhela Zhiti, Michaela Rusková, Maria M. Magiera, Mengzhe Wang, Karin A. Ziegler, Torben J. Hausrat, Anselm I. Ugwuja, Shreyangi Chakraborty, Stefan Engelhardt, Matthias Kneussel, Martin Balastik, Carsten Janke, Thomas Misgeld & Monika S. Brill
Nature Communications volume 16, Article number: 5384 (2025)
Engler J, Kim EJ, Kim D, Shibata NM, Lynderup EM, Vendelbo MH, Akdogan B, Sailer J, Fontes A, Eberhagen C, Rieder T, Reinold Q, Lee H, Park D, Jung C, Im W, Wudy SI, Kleigrewe K, Engelhardt S, DiSpirito AA, Sandahl TD, Medici V, Eun SY, Zischka H.
Epub 2025 Dec
Allele-specific genomics decodes gene targets and mechanisms of the non-coding genome
Tim P Hasenbein, Sarah Hoelzl, Stefan Engelhardt, Daniel Andergassen
Nucleic Acids Research 2025
Aging promotes reactivation of the Barr body at distal chromosome regions
Sarah Hoelzl, Tim P. Hasenbein, Stefan Engelhardt, Daniel Andergassen
Nature Aging 2025
Neural Mechanisms in Cardiovascular Health and Disease
Ziegler KA, Engelhardt S, Carnevale D, McAlpine CS, Guzik TJ, Dimmeler S, Swirski FK.
Circ Res. 2025 May
Ganglionic Inflammation in a Patient With Takotsubo Syndrome
Karin A Ziegler, Manuel Zeitler, Sandro Meunier, Inga Sinicina, Tim P Hasenbein, Daniel Andergassen, Anton Bomhard, Reginald VCT van der Kwast, Stefan Engelhardt
Circulation 2025
Circular RNAs increase during vascular cell differentiation and are biomarkers for vascular disease
Northoff BH, Herbst A, Wenk C, Weindl L, Gäbel G, Brezski A, Zarnack K, Küpper A, Dimmeler S, Moretti A, Laugwitz KL, Engelhardt S, Maegdefessel L, Boon RA, Doppler S, Dreßen M, Lahm H, Lange R, Krane M, Krohn K, Kohlmaier A, Holdt LM, Teupser D. Circular RNAs increase during vascular cell differentiation and are biomarkers for vascular disease.
Cardiovasc Res. 2025 Apr
2024
Tim P. Hasenbein, Sarah Hoelzl, Zachary D. Smith, Chiara Gerhardinger, Marion O. C. Gonner, Antonio Aguilar-Pimentel, Oana V. Amarie, Lore Becker, Julia Calzada-Wack, Nathalia R. V. Dragano, Patricia da Silva-Buttkus, Lillian Garrett, Sabine M. Hölter, Markus Kraiger, Manuela A. Östereicher, Birgit Rathkolb, Adrián Sanz-Moreno, Nadine Spielmann, Wolfgang Wurst, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Alexander Meissner, Stefan Engelhardt, John L. Rinn, Daniel Andergassen.
Nature Communications volume 15, Article number: 10631 (2024)
Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis
Gaertner F, Ishikawa-Ankerhold H, Stutte S, Fu W, Weitz J, Dueck A, Nelakuditi B, Fumagalli V, van den Heuvel D, Belz L, Sobirova G, Zhang Z, Titova A, Navarro AM, Pekayvaz K, Lorenz M, von Baumgarten L, Kranich J, Straub T, Popper B, Zheden V, Kaufmann WA, Guo C, Piontek G, von Stillfried S, Boor P, Colonna M, Clauß S, Schulz C, Brocker T, Walzog B, Scheiermann C, Aird WC, Nerlov C, Stark K, Petzold T, Engelhardt S, Sixt M, Hauschild R, Rudelius M, Oostendorp RAJ, Iannacone M, Heinig M & Massberg S.
Nature. 2024 Jul;631(8021):645-653.
Sultan I, Ramste M, Peletier P, Hemanthakumar KA, Ramanujam D, Tirronen A, von Wright Y, Antila S, Saharinen P, Eklund L, Mervaala E, Ylä-Herttuala S, Engelhardt S, Kivelä R & Alitalo K.
Circ Res. 2024 May 24;134(11):1465-1482.
Schröper T, Mehrkens D, Leiss V, Tellkamp F, Engelhardt S, Herzig S, Birnbaumer L, Nürnberg B, Matthes J.
Naunyn Schmiedebergs Arch Pharmacol. 2024
In Vivo Silencing of Regulatory Elements Using a Single AAV-CRISPRi Vector
Laurette P, Cao C, Ramanujam D, Schwaderer M, Lueneburg T, Kuss S, Weiss L, Dilshat R, Furlong EEM, Rezende F, Engelhardt S & Gilsbach R.
Circ Res. 2024 Jan 19;134(2):223-225.
Haberman ER, Sarker G, Arús BA, Ziegler KA, Meunier S, Martínez-Sánchez N, Freibergerová E, Yilmaz-Özcan S, Fernández-González I, Zentai C, O'Brien CJO, Grainger DE, Sidarta-Oliveira D, Chakarov S, Raimondi A, Iannacone M, Engelhardt S, López M, Ginhoux F & Domingos AI.
Immunity. 2024. 57(1):141-152.e5.
Genetic Variatns of Adrenoreceptors
Ahles A, Engelhardt S.
Handb Exp Pharmacol. 2024;285:27-54
Weinberger T, Denise M, Joppich M, Fischer M, Garcia Rodriguez C, Kumaraswami K, Wimmler V, Ablinger S, Räuber S, Fang J, Liu L, Liu WH, Winterhalter J, Lichti J, Thomas L, Esfandyari D, Percin G, Matin S, Hidalgo A, Waskow C, Engelhardt S, Todica A, Zimmer R, Pridans C, Gomez Perdiguero E & Schulz C.
Elife. 2024.12:RP89377.
2023
Immobility-associated thromboprotection is conserved across mammalian species from bear to human
Thienel M, Müller-Reif JB, Zhang Z, Ehreiser V, Huth J, Shchurovska K, Kilani B, Schweizer L, Geyer PE, Zwiebel M, Novotny J, Lüsebrink E, Little G, Orban M, Nicolai L, El Nemr S, Titova A, Spannagl M, Kindberg J, Evans AL, Mach O, Vogel M, Tiedt S, Ormanns S, Kessler B, Dueck A, Friebe A, Jørgensen PG, Majzoub-Altweck M, Blutke A, Polzin A, Stark K, Kääb S, Maier D, Gibbins JM, Limper U, Frobert O, Mann M, Massberg S, Petzold T.
Science. 2023 Apr 14;380(6641):178-187.
Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype
Maus M, López-Polo V, Mateo L, Lafarga M, Aguilera M, De Lama E, Meyer K, Sola A, Lopez-Martinez C, López-Alonso I, Guasch-Piqueras M, Hernandez-Gonzalez F, Chaib S, Rovira M, Sanchez M, Faner R, Agusti A, Diéguez-Hurtado R, Ortega S, Manonelles A, Engelhardt S, Monteiro F, Stephan-Otto Attolini C, Prats N, Albaiceta G, Cruzado JM & Serrano M.
Nat Metab. 2023; 5(12): 2111–2130.
Genetic Variants of Adrenoceptors
Ahles A & Engelhardt S.
Handb Exp Pharmacol. 2023
Schröper T, Mehrkens D, Leiss V, Tellkamp F, Engelhardt S, Herzig S, Birnbaumer L, Nürnberg B & Matthes J.
Naunyn Schmiedebergs Arch Pharmacol. 2024; 397(4): 2401–2420.
Identification of hypertrophy-modulating Cullin-RING ubiquitin ligases in primary cardiomyocytes
Fischer M, Jakab M, Hirt MN, Werner TR, Engelhardt S & Sarikas A.
Front Physiol. 2023; 14: 1134339.
Hoffmann J, Hanß S, Kraus M, Schaller J, Schäfer C, Stahl D, Anker SD, Anton G, Bahls T, Blankenberg S, Blumentritt A, Boldt LH, Cordes S, Desch S, Doehner W, Dörr M, Edelmann F, Eitel I, Endres M, Engelhardt S, Erdmann J, Eulenburg K, Falk V, Felix SB, Frank D, Franke T, Frey N, Friede T, Geidel L, Germans L, Grabmaier U, Halle M, Hausleiter J, Jakobi V, Jebran AF, Jobs A, Kääb S, Karakas M, Katus HA, Klatt A, Knosalla C, Krebser J, Landmesser U, Lee M, Lehnert K, Lesser S, Leyh K, Lorbeer R, Mach-Kolb S, Meder B, Nagel E, Nolte CH, Parwani AS, Petersmann A, Puls M, Rau H, Reiser M, Rienhoff O, Scharfe T, Schattschneider M, Scheel H, Schnabel RB, Schuster A, Schmitt B, Seidler T, Seiffert M, Stähli BE, Stas A, J Stocker T, von Stülpnagel L, Thiele H, Wachter R, Wakili R, Weis T, Weitmann K, Wichmann HE, Wild P, Zeller T, Hoffmann W, Zeisberg EM, Zimmermann WH, Krefting D, Kühne T, Peters A, Hasenfuß G, Massberg S, Sommer T, Dimmeler S, Eschenhagen T & Nauck M.
Clin Res Cardiol. 2023. 112(7):923-941.
Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease
Karin A Ziegler, Andrea Ahles, Anne Dueck, Dena Esfandyari, Pauline Pichler, Karolin Weber, Stefan Kotschi, Alexander Bartelt, Inga Sinicina, Matthias Graw, Heinrich Leonhardt, Ludwig T Weckbach, Steffen Massberg, Martina Schifferer, Mikael Simons, Luciano Hoeher, Jie Luo, Ali Ertürk, Gabriele G Schiattarella, Yassine Sassi, Thomas Misgeld & Stefan Engelhardt.
Science. 2023, 381,285-290.
Christina Beck, Deepak Ramanujam, Paula Vaccarello, Florenc Widenmeyer, Martin Feuerherd, Cho-Chin Cheng, Anton Bomhard, Tatiana Abikeeva, Julia Schädler, Jan-Peter Sperhake, Matthias Graw, Seyer Safi, Hans Hoffmann, Claudia A. Staab-Weijnitz, Roland Rad, Ulrike Protzer, Thomas Frischmuth & Stefan Engelhardt.
Nat Commun. 2023. 14, 4564.
2022
Fangfang Zhang, Anna B Meier, Daniel Sinnecker, Stefan Engelhardt, Peter Lipp, Karl-Ludwig Laugwitz, Tatjana Dorn & Alessandra Moretti.
Stem Cell Res. 2022. 61, 102785.
Uncovering the molecular identity of cardiosphere-derived cells (CDCs) by single-cell RNA sequencing
Palgit-S. Kogan, Felix Wirth, Archana Tomar, Jonatan Darr, Raffaele Teperino, Harald Lahm, Martina Dreßen, Nazan Puluca, Zhong Zhang, Irina Neb, Nicole Beck, Tatjana Luzius, Luis de la Osa de la Rosa, Kathrin Gärtner, Corinna Hüls, Reinhard Zeidler, Deepak Ramanujam, Stefan Engelhardt, Catharina Wenk, Lesca M. Holdt, Mimmi Mononen, Makoto Sahara, Julie Cleuziou, Jürgen Hörer, Rüdiger Lange, Markus Krane & Stefanie A. Doppler.
Basic Res Cardiol. 2022. 8, 117(1), 11.
CRISPR somatic genome engineering and cancer modeling in the mouse pancreas and liver
Thorsten Kaltenbacher, Jessica Löprich, Roman Maresch, Julia Weber, Sebastian Müller, Rupert Oellinger, Nina Groß, Joscha Griger, Niklas de Andrade Krätzig, Petros Avramopoulos, Deepak Ramanujam, Sabine Brummer, Sebastian A. Widholz, Stefanie Bärthel, Chiara Falcomatà, Anja Pfaus, Ahmed Alnatsha, Julia Mayerle, Marc Schmidt-Supprian, Maximilian Reichert, Günter Schneider, Ursula Ehmer, Christian J. Braun, Dieter Saur, Stefan Engelhardt & Roland Rad.
Nat Protoc. 2022. 17(4), 1142-1188.
Endothelial deletion of the cytochrome P450 reductase leads to cardiac remodelling
Melina Lopez, Pedro F. Malacarne, Deepak P. Ramanujam, Timothy Warwick, Niklas Müller, Jiong Hu, Matthias Dewenter, Andreas Weigert, Stefan Günther, Ralf Gilsbach, Stefan Engelhardt, Ralf P. Brandes & Flávia Rezende.
Front Physiol. 2022, 2, 13, 1056369.
MicroRNAs as therapeutic targets in cardiovascular disease
Bernhard Laggerbauer & Stefan Engelhardt.
J Clin Invest. 2022, 1, 132(11), e159179.
Nicht kodierende Ribonukleinsäure im kardiovaskulären System
S. Engelhardt, S. Dimmeler, C. Heim, C. Bär, T. Böttger, R. Boon, R. P. Brandes, T. Braun, A. Dueck, J. Gagneur, P.Grote, L.M. Holdt, N. Jaé , J. Krishnan, C. Kupatt, K.-L. Laugwitz, M. S. Leisegang, L. Maegdefessel, T. Meitinger, A. Moretti, M. Müller-McNicoll, M. Sattler, A. Schnieke, M. Schulz, H. Schunkert, H. Schwalbe, D. Teupser, T. Thum, C.Weber, I. Wittig & K. Zarnack
Der Kardiologe. 2022, 100–108.
MicroRNA-365 regulates human cardiac action potential duration
Esfandyari D, Idrissou BMG, Hennis K, Avramopoulos P, Dueck A, El-Battrawy I, Grüter L, Meier MA, Näger AC, Ramanujam D, Dorn T, Meitinger T, Hagl C, Milting H, Borggrefe M, Fenske S, Biel M, Dendorfer A, Sassi Y, Moretti A & Engelhardt S.
Nat. Commun. 2022, 11, 13(1), 220.
2021
The long non-coding RNA NRON promotes the development of cardiac hypertrophy in the murine heart
Jeannine Hoepfner, Julia Leonardy, Dongchao Lu, Kevin Schmidt, Hannah J Hunkler, Sinje Biß, Ariana Foinquinos, Ke Xiao, Kumarswamy Regalla, Deepak Ramanujam, Stefan Engelhardt, Christian Bär & Thomas Thum.
Mol Ther. 2021, 1525-0016(21), 00635-3.
From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo
Daniel Andergassen & John L Rinn.
Nat Rev Genet. 2022 Apr;23(4):229-243.
Daniel Andergassen, Zachary D Smith, Helene Kretzmer, John L Rinn & Alexander Meissner.
Dev Cell. 2021, 8,56(21), 2995-3005.
Titin Circular RNAs Create a Back-Splice Motif Essential for SRSF10 Splicing
Anke J Tijsen, Lucía Cócera Ortega, Yolan J Reckman, Xiaolei Zhang, Ingeborg van der Made, Simona Aufiero, Jiuru Li, Selina C Kamps, Anouk van den Bout, Harsha D Devalla, Karin Y van Spaendonck-Zwarts, Stefan Engelhardt, Lior Gepstein, James S Ware & Yigal M Pinto.
Circulation. 2021, 13, 143(15),1502-1512.
Renal AAV2-Mediated Overexpression of Long Non-Coding RNA H19 Attenuates Ischemic Acute Kidney Injury Through Sponging of microRNA-30a-5p
George Haddad, Malte Kölling, Urs A Wegmann, Angela Dettling, Harald Seeger, Roland Schmitt, Inga Soerensen-Zender, Hermann Haller, Andreas D Kistler, Anne Dueck, Stefan Engelhardt, Thomas Thum, Thomas F Mueller, Rudolf P Wüthrich & Johan M Lorenzen.
J Am Soc Nephrol. 2021, 32(2), 323-341.
Glycosylation-dependent cleavage of the human β 1-adrenoceptor
Andrea Ahles & Stefan Engelhardt
J Mol Cell Cardiol. 2021, 154, 154-155.
DGK and DZHK position paper on genome editing: basic science applications and future perspective
Ralf P Brandes, Anne Dueck, Stefan Engelhardt, Manuel Kaulich, Christian Kupatt, Maria Teresa De Angelis, Matthias S Leisegang, Ferdinand le Noble, Alessandra Moretti, Oliver J Müller, Boris V Skryabin, Thomas Thum, Wolfgang Wurst
Basic Res Cardiol. 2021 15, 116(1), 2.
Completion of neuronal remodeling prompts myelination along developing motor axon branches
Mengzhe Wang, Tatjana Kleele, Yan Xiao, Gabriela Plucinska, Petros Avramopoulos, Stefan Engelhardt, Markus H Schwab, Matthias Kneussel, Tim Czopka, Diane L Sherman, Peter J Brophy, Thomas Misgeld & Monika S Brill.
J Cell Biol. (2021) 220 (4), 201911114.
Deepak Ramanujam, Anna Patricia Schön, Christina Beck, Paula Vaccarello, Giulia Felician, Anne Dueck, Dena Esfandyari, Gunter Meister, Thomas Meitinger, Christian Schulz & Stefan Engelhardt.
Circulation. 2021, 143(15), 1513–1525.
2020
Melanie Anger, Florian Scheufele, Deepak Ramanujam, Kathleen Meyer , Hidehiro Nakajima , Loren J Field, Stefan Engelhardt & Antonio Sarikas.
PloS One. 2020, 15(12), 0244096.
Metavinculin modulates force transduction in cell adhesion sites
Kanoldt V, Kluger C, Barz C, Schweizer AL, Ramanujam D, Windgasse L, Engelhardt S, Chrostek-Grashoff A & Grashoff C.
Nat Commun. 2020, 11(1), 6403.
Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation
Weinberger T, Esfandyari D, Messerer D, Percin G, Schleifer C, Thaler R, Liu L, Stremmel C, Schneider V, Vagnozzi RJ, Schwanenkamp J, Fischer M, Busch K, Klapproth K, Ishikawa-Ankerhold H, Klösges L, Titova A, Molkentin JD, Kobayashi Y, Engelhardt S, Massberg S, Waskow C, Perdiguero EG & Schulz C.
Nat. Commun. 2020, 11(1), 4549.
Bär C, Chatterjee S, Falcão Pires I, Rodrigues P, Sluijter JPG, Boon RA, Nevado RM, Andrés V, Sansonetti M, de Windt L, Ciccarelli M, Hamdani N, Heymans S, Figuinha Videira R, Tocchetti CG, Giacca M, Zacchigna S, Engelhardt S, Dimmeler S, Madonna R & Thum T.
Cardiovasc Res. 2020, 116(11), 1805-1819.
LifeTime and improving European healthcare through cell-based interceptive medicine
Rajewsky N, Almouzni G, Gorski SA, Aerts S, Amit I, Bertero MG, Bock C, Bredenoord AL, Cavalli G, Chiocca S, Clevers H, De Strooper B, Eggert A, Ellenberg J, Fernández XM, Figlerowicz M, Gasser SM, Hubner N, Kjems J, Knoblich JA, Krabbe G, Lichter P, Linnarsson S, Marine JC, Marioni J, Marti-Renom MA, Netea MG, Nickel D, Nollmann M, Novak HR, Parkinson H, Piccolo S, Pinheiro I, Pombo A, Popp C, Reik W, Roman-Roman S, Rosenstiel P, Schultze JL, Stegle O, Tanay A, Testa G, Thanos D, Theis FJ, Torres-Padilla ME, Valencia A, Vallot C, van Oudenaarden A, Vidal M & Voet T.
Nature. 2020, 587(7834), 377-386.
Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction
Trembinski DJ, Bink DI, Theodorou K, Sommer J, Fischer A, van Bergen A, Kuo CC, Costa IG, Schürmann C, Leisegang MS, Brandes RP, Alekseeva T, Brill B, Wietelmann A, Johnson CN, Spring-Connell A, Kaulich M, Werfel S, Engelhardt S, Hirt MN, Yorgan K, Eschenhagen T, Kirchhof L, Hofmann P, Jaé N, Wittig I, Hamdani N, Bischof C, Krishnan J, Houtkooper RH, Dimmeler S & Boon RA.
Nat Commun. 2020, 11(1), 2039.
Targeting muscle-enriched long non-coding RNA H19 reverses pathological cardiac hypertrophy
Viereck J, Bührke A, Foinquinos A, Chatterjee S, Kleeberger JA, Xiao K, Janssen-Peters H, Batkai S, Ramanujam D, Kraft T, Cebotari S, Gueler F, Beyer AM, Schmitz J, Bräsen JH, Schmitto JD, Gyöngyösi M, Löser A, Hirt MN, Eschenhagen T, Engelhardt S, Bär C & Thum T.
Eur Heart J. 2020 41(36), 3462-3474.
AntimiR-21 Prevents Myocardial Dysfunction in a Pig Model of Ischemia/Reperfusion Injury
Hinkel R, Ramanujam D, Kaczmarek V, Howe A, Klett K, Beck C, Dueck A, Thum T, Laugwitz KL, Maegdefessel L, Weber C, Kupatt C & Engelhardt S.
J Am Coll Cardiol. 2020, 75(15), 1788-1800.
2019
Correlation of online assessment parameters with summative exam performance in undergraduate medical education of pharmacology: a prospective cohort study
Kühbeck F, Berberat PO, Engelhardt S & Sarikas A.
BMC Med Educ. 2019, 19(1), 412.
miR-212/132 Cluster Modulation Prevents Doxorubicin-Mediated Atrophy and Cardiotoxicity
Gupta SK, Garg A, Avramopoulos P, Engelhardt S, Streckfuss-Bömeke K, Batkai S & Thum T.
Mol Ther. 2019, 27(1), 17-28.
2018
Nuclear calcineurin is a sensor for detecting Ca2+ release from the nuclear envelope via IP3R
Olivares-Florez S, Czolbe M, Riediger F, Seidlmayer L, Williams T, Nordbeck P, Strasen J, Glocker C, Jänsch M, Eder-Negrin P, Arias-Loza P, Mühlfelder M, Plačkić J, Heinze KG, Molkentin JD, Engelhardt S, Kockskämper J & Ritter O.
J Mol Med (Berl). 2018, 96(11), 1239-1249.
H19 Induces Abdominal Aortic Aneurysm Development and Progression
Li DY, Busch A, Jin H, Chernogubova E, Pelisek J, Karlsson J, Sennblad B, Liu S, Lao S, Hofmann P, Bäcklund A, Eken SM, Roy J, Eriksson P, Dacken B, Ramanujam D, Dueck A, Engelhardt S, Boon RA, Eckstein HH, Spin JM, Tsao PS & Maegdefessel L.
Circulation. 2018, 138(15), 1551-1568.
Ziegler KA, Ahles A, Wille T, Kerler J, Ramanujam D & Engelhardt S.
Cardiovasc Res. 2018, 114(2), 291-299.
Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives
Poller W, Dimmeler S, Heymans S, Zeller T, Haas J, Karakas M, Leistner DM, Jakob P, Nakagawa S, Blankenberg S, Engelhardt S, Thum T, Weber C, Meder B, Hajjar R & Landmesser U.
Eur Heart J. 2018, 39(29), 2704-2716.
2017
Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling
Wang J, Hanada K, Staus DP, Makara MA, Dahal GR, Chen Q, Ahles A, Engelhardt S & Rockman HA.
Nat Commun. 2017, 8(1), 1706.
Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling
Sassi Y, Avramopoulos P, Ramanujam D, Grüter L, Werfel S, Giosele S, Brunner AD, Esfandyari D, Papadopoulou AS, De Strooper B, Hübner N, Kumarswamy R, Thum T, Yin X, Mayr M, Laggerbauer B & Engelhardt S.
Nat Commun. 2017, 8(1), 1614.
Cardiomyocyte proliferation prevents failure in pressure overload but not volume overload
Toischer K, Zhu W, Hünlich M, Mohamed BA, Khadjeh S, Reuter SP, Schäfer K, Ramanujam D, Engelhardt S, Field LJ & Hasenfuss G.
J Clin Invest. 2017, 127(12), 4285-4296.
Preferential microRNA targeting revealed by in vivo competitive binding and differential Argonaute immunoprecipitation
Werfel S, Leierseder S, Ruprecht B, Kuster B & Engelhardt S.
Nucleic Acids Res. 2017, 45(17), 10218-10228.
Two serines in the distal C-terminus of the human β1-adrenoceptor determine β-arrestin2 recruitment
Hinz, L, Ahles, A, Ruprecht, B, Küster, B & Engelhardt, S.
PLoS ONE 2017, 12(5), e0176450.
Circular RNAs in heart failure
Devaux Y, Creemers EE, Boon RA, Werfel S, Thum T, Engelhardt S, Dimmeler S & Squire I.
Eur J Heart Fail. 2017, 19(6), 701-709.
2016
Iron deficiency anemia in cyclic gmp kinase knockout mice
Angermeier E, Domes K, Lukowski R, Schlossmann J, Rathkolb B, Angelis MH & Hofmann F.
Haematologica 2016, 101(2), e48-e51.
Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the β2 adrenergic receptor
Patriarchi T, Qian H, Di Biase V, Malik ZA, Chowdhury D, Price JL, Hammes EA, Buonarati OR, Westenbroek RE, Catterall W., Hofmann F, Xiang YK, Murphy GG, Chen CY, Navedo MF & Hell JW.
EMBO Journal 2016, 35(12), 1330-1345.
Involvement of cyclic guanosine monophosphate-dependent protein kinase I in renal antifibrotic effects of serelaxin
Wetzl V, Schinner E, Kees F, Hofmann F, Faerber L & Schlossmann J.
Frontiers in Pharmacology 2016, 12(7),195.
Viral Vector-Based Targeting of miR-21 in Cardiac Nonmyocyte Cells Reduces Pathologic Remodeling of the Heart
Ramanujam D, Sassi Y, Laggerbauer B & Engelhardt S.
Mol Ther. 2016, 24(11), 1939-1948.
Peptidase inhibitor 16 is a membrane-tethered regulator of chemerin processing in the myocardium
Regn M, Laggerbauer B, Jentzsch C, Ramanujam D, Ahles A, Sichler S, Calzada-Wack J, Koenen RR, Braun A, Nieswandt B & Engelhardt S.
J Mol Cell Cardiol. 2016, 99, 57-64.
Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination
Brill MS, Kleele T, Ruschkies L, Wang M, Marahori NA, Reuter MS, Hausrat TJ, Weigand E, Fisher M, Ahles A, Engelhardt S, Bishop DL, Kneussel M & Misgeld T.
Neuron. 2016, 92(4), 845-856.
Characterization of circular RNAs in human, mouse and rat hearts
Werfel S, Nothjunge S, Schwarzmayr T, Strom TM, Meitinger T & Engelhardt S.
J Mol Cell Cardiol. 2016, 98, 103-7.
Essential Role for Premature Senescence of Myofibroblasts in Myocardial Fibrosis
Meyer K, Hodwin B, Ramanujam D, Engelhardt S & Sarikas A.
J Am Coll Cardiol. 2016, 67(17), 2018-28.
Long noncoding RNA Chast promotes cardiac remodeling
Viereck J, Kumarswamy R, Foinquinos A, Xiao K, Avramopoulos P, Kunz M, Dittrich M5, Maetzig T, Zimmer K, Remke J, Just A, Fendrich J, Scherf K, Bolesani E, Schambach A, Weidemann F, Zweigerdt R, de Windt LJ, Engelhardt S, Dandekar T, Batkai S & Thum T.
Sci Transl Med. 2016, 8(326), 326ra22.
2015
MicroRNA Augmentation of Bone Marrow-Derived Cell Therapy
Engelhardt S & Sassi Y.
J Am Coll Cardiol. 2015, 66(20), 2227-9.
MicroRNA-223 dose levels fine tune proliferation and differentiation in human cord blood progenitors and acute myeloid leukemia
Gentner B, Pochert N, Rouhi A, Boccalatte F, Plati T, Berg T, Sun SM, Mah SM, Mirkovic-Hösle M, Ruschmann J, Muranyi A, Leierseder S, Argiropoulos B, Starczynowski DT, Karsan A, Heuser M, Hogge D, Camargo FD, Engelhardt S, Döhner H, Buske C, Jongen-Lavrencic M, Naldini L, Humphries RK & Kuchenbauer F.
Exp Hematol. 2015, 43(10), 858-868.e7.
Lack of Gαi2 leads to dilative cardiomyopathy and increased mortality in β1-adrenoceptor overexpressing mice
Keller K, Maass M, Dizayee S, Leiss V, Annala S, Köth J, Seemann WK, Müller-Ehmsen J, Mohr K, Nürnberg B, Engelhardt S, Herzig S, Birnbaumer L & Matthes J.
Cardiovasc Res. 2015, 108(3), 348-56.
Murine cardiac growth, TRPC channels, and cGMP kinase I
Domes K, Patrucco E, Loga F, Dietrich A, Birnbaumer L, Wegener JW & Hofmann F.
Pflugers Arch. 2015, 467(10), 2229-34.
Regulation of the Na(+)-K(+)-2Cl(-) cotransporter by cGMP/cGMP-dependent protein kinase I after furosemide administration
Limmer F, Schinner E, Castrop H, Vitzthum H, Hofmann F & Schlossmann J.
FEBS J. 2015, 282(19), 3786-98.
Development of an intein-mediated split-Cas9 system for gene therapy
Truong DJ, Kühner K, Kühn R, Werfel S, Engelhardt S, Wurst W & Ortiz O.
Nucleic Acids Res. 2015, 43(13), 6450-8.
Intercellular miRNA Traffic
Ramanujam D & Engelhardt S.
Circ Res. 2015, 116(11), 1726-8.
Use of learning media by undergraduate medical students in pharmacology: a prospective cohort study
Gutmann J, Kühbeck F, Berberat PO, Fischer MR, Engelhardt S & Sarikas A.
PLoS One. 2015, 10(4), e0122624.
Interhelical interaction and receptor phosphorylation regulate the activation kinetics of different human β1-adrenoceptor variants
Ahles A, Rodewald F, Rochais F, Bünemann M & Engelhardt S.
J Biol Chem. 2015, 290(3), 1760-9.
CaV1.2 and CaV1.3 channel hyperactivation in mouse islet β cells exposed to type 1 diabetic serum
Yang G, Shi Y, Yu J, Li Y, Yu L, Welling A, Hofmann F, Striessnig J, Juntti-Berggren L, Berggren PO & Yang SN.
Cell Mol Life Sci. 2015, 72(6), 1197-207.
2014
Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation
Sassi Y, Ahles A, Truong DJ, Baqi Y, Lee SY, Husse B, Hulot JS, Foinquinos A, Thum T, Müller CE, Dendorfer A, Laggerbauer B & Engelhardt S.
J Clin Invest. 2014, 124(12), 5385-97.
FHL2 expression and variants in hypertrophic cardiomyopathy
Friedrich FW, Reischmann S, Schwalm A, Unger A, Ramanujam D, Münch J, Müller OJ, Hengstenberg C, Galve E, Charron P, Linke WA, Engelhardt S, Patten M, Richard P, van der Velden J, Eschenhagen T, Isnard R & Carrier L.
Basic Res Cardiol. 2014, 109(6), 451.
Rapid and highly efficient inducible cardiac gene knockout in adult mice using AAV-mediated expression of Cre recombinase
Werfel S, Jungmann A, Lehmann L, Ksienzyk J, Bekeredjian R, Kaya Z, Leuchs B, Nordheim A, Backs J, Engelhardt S, Katus HA & Müller OJ.
Cardiovasc Res. 2014, 104(1), 15-23.
Accuracy and completeness of drug information in Wikipedia: a comparison with standard textbooks of pharmacology
Kräenbring J, Monzon Penza T, Gutmann J, Muehlich S, Zolk O, Wojnowski L, Maas R, Engelhardt S & Sarikas A.
PLoS One. 2014, 9(9), e106930.
Polymorphic variants of adrenoceptors: pharmacology, physiology, and role in disease
Ahles A & Engelhardt S.
Pharmacol Rev. 2014, 66(3), 598-637.
Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy
Bang C, Batkai S, Dangwal S, Gupta SK, Foinquinos A, Holzmann A, Just A, Remke J, Zimmer K, Zeug A, Ponimaskin E, Schmiedl A, Yin X, Mayr M, Halder R, Fischer A, Engelhardt S, Wei Y, Schober A, Fiedler J & Thum T.
J Clin Invest. 2014, 124(5), 2136-46.
OnlineTED.com-a novel web-based audience response system for higher education. A pilot study to evaluate user acceptance
Kühbeck F, Engelhardt S & Sarikas A.
GMS Z Med Ausbild. 2014, 31(1), Doc5.
Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression
Zhang Q, Chibalina MV, Bengtsson M, Groschner LN, Ramracheya R, Rorsman NJ, Leiss V, Nassar MA, Welling A, Gribble FM, Reimann F, Hofmann F, Wood JN, Ashcroft FM & Rorsman P.
J Physiol. 2014, 592(21), 4677-96.
Inhibition of Cullin-RING E3 ubiquitin ligase 7 by simian virus 40 large T antigen
Hartmann T, Xu X, Kronast M, Muehlich S, Meyer K, Zimmermann W, Hurwitz J, Pan ZQ, Engelhardt S & Sarikas A.
Proc Natl Acad Sci U S A. 2014, 111(9), 3371-6.
Reduced excitability of gp130-deficient nociceptors is associated with increased voltage-gated potassium currents and Kcna4 channel upregulation
Langeslag M, Malsch P, Welling A & Kress M.
Pflugers Arch. 2014, 466(11), 2153-65.
Evidence for a regulatory role of Cullin-RING E3 ubiquitin ligase 7 in insulin signaling
Scheufele F, Wolf B, Kruse M, Hartmann T, Lempart J, Muehlich S, Pfeiffer AF, Field LJ, Charron MJ, Pan ZQ, Engelhardt S & Sarikas A.
Cell Signal. 2014, 26(2), 233-9.
Archive: 2013-2003
2013
Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome
Bellin M, Casini S, Davis RP, D'Aniello C, Haas J, Ward-van Oostwaard D, Tertoolen LG, Jung CB, Elliott DA, Welling A, Laugwitz KL, Moretti A & Mummery CL.
EMBO J. 2013, 32(24), 3161-75.
Coinciding functions for miR-145 in vascular smooth muscle and cardiac fibroblasts
Engelhardt S & Leierseder S.
J Mol Cell Cardiol. 2013, 65, 105-7.
microRNA-22 Promotes Heart Failure through Coordinate Suppression of PPAR/ERR-Nuclear Hormone Receptor Transcription
Gurha P, Wang T, Larimore AH, Sassi Y, Abreu-Goodger C, Ramirez MO, Reddy AK, Engelhardt S, Taffet GE, Wehrens XH, Entman ML & Rodriguez A.
PLoS One. 2013, 8(9), e75882.
MiR-223 is dispensable for platelet production and function in mice
Leierseder S, Petzold T, Zhang L, Loyer X, Massberg S & Engelhardt S.
Thromb Haemost. 2013, 110(6), 1207-14.
Dynamics of Gαi1 interaction with type 5 adenylate cyclase reveal the molecular basis for high sensitivity of Gi-mediated inhibition of cAMP production
Milde M, Rinne A, Wunder F, Engelhardt S & Bünemann M.
Biochem J. 2013, 454(3), 515-23.
The human transcriptome is enriched for miRNA-binding sites located in cooperativity-permitting distance
Rinck A, Preusse M, Laggerbauer B, Lickert H, Engelhardt S & Theis FJ.
RNA Biol. 2013, 10(7), 1125-35.
MiR-378 Controls Cardiac Hypertrophy by Combined Repression of MAP Kinase Pathway Factors
Ganesan J, Ramanujam D, Sassi Y, Ahles A, Jentzsch C, Werfel S, Leierseder S, Loyer X, Giacca M, Zentilin L, Thum T, Laggerbauer B & Engelhardt S.
Circulation. 2013, 127(21), 2097-106.
Internet discussion forums as part of a student-centred teaching concept of pharmacology
Sucha M, Engelhardt S & Sarikas A.
GMS Z Med Ausbild. 2013, 30(1), Doc2.
Pharmacases.de - a student-centered e-learning project of clinical pharmacology
Zollner B, Sucha M, Berg C, Muß N, Amann P, Amann-Neher B, Oestreicher D, Engelhardt S & Sarikas A.
Med Teach. 2013, 35(3), 251-3.
2012
The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy
Ucar A, Gupta SK, Fiedler J, Erikci E, Kardasinski M, Batkai S, Dangwal S, Kumarswamy R, Bang C, Holzmann A, Remke J, Caprio M, Jentzsch C, Engelhardt S, Geisendorf S, Glas C, Hofmann TG, Nessling M, Richter K, Schiffer M, Carrier L, Napp LC, Bauersachs J, Chowdhury K & Thum T.
Nat Commun. 2012, 3, 1078.
Small RNA biomarkers come of age
Engelhardt S
J Am Coll Cardiol. 2012, 60(4), 300-3.
The bispecific SDF1-GPVI fusion protein preserves myocardial function after transient ischemia in mice
Ziegler M, Elvers M, Baumer Y, Leder C, Ochmann C, Schönberger T, Jürgens T, Geisler T, Schlosshauer B, Lunov O, Engelhardt S, Simmet T & Gawaz M.
Circulation. 2012, 125(5), 685-96.
Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes
Sassi Y, Abi-Gerges A, Fauconnier J, Mougenot N, Reiken S, Haghighi K, Kranias EG, Marks AR, Lacampagne A, Engelhardt S, Hatem SN, Lompre AM & Hulot JS.
FASEB J. 2012, 26(3), 1009-17.
A phenotypic screen to identify hypertrophy-modulating microRNAs in primary cardiomyocytes
Jentzsch C, Leierseder S, Loyer X, Flohrschütz I, Sassi Y, Hartmann D, Thum T, Laggerbauer B & Engelhardt S.
J Mol Cell Cardiol. 2012 52(1), 13-20.
2011
MicroRNA-24 regulates vascularity after myocardial infarction
Fiedler J, Jazbutyte V, Kirchmaier B, Galuppo P, Kneitz S, Pena JTR, Sohn-Lee C, Soutschek J, Brand T, Tuschl T, Ertl G, Engelhardt S, Bauersachs J & Thum T.
Circulation. 2011, 124(6), 720-730.
A critical role for STIM1 in cardiac hypertrophy
Hulot JS, Fauconnier J, Ramanujam D, Chaanine A, Aubart F, Sassi Y, Merkle S, Cazorla O, Ouille A, Dupuis M, Hadri L, Jeong D, Muehlstedt S, Schmitt J, Braun A, Benard L, Saliba Y, Laggerbauer B, Nieswandt B, Lacampagne A, Hajjar R, Lompre AM & Engelhardt S.
Circulation. 2011, 124(7), 796–805.
A Polymorphism-Specific "Memory" Mechanism in the β2-Adrenergic Receptor
Ahles A, Rochais F, Frambach T, Bünemann M & Engelhardt S.
Sci. Signal. 2011, 4(185):ra53.
Facilitation and Ca2+-dependent Inactivation Are Modified by Mutation of the Cav1.2 Channel IQ Motif
Poomvanicha M, Wegener JW, Blaich A, Fischer S, Domes K, Moosmang S & Hofmann F.
J Biol Chem. 2011, 286(30), 26702-7.
Disrupting the EMMPRIN (CD147)-cyclophilin A interaction reduces infarct size and preserves systolic function after myocardial ischemia and reperfusion
Seizer P, Ochmann C, Schönberger T, Zach S, Rose M, Borst O, Klingel K, Kandolf R, MacDonald HR, Nowak RA, Engelhardt S, Lang F, Gawaz M & May AE.
Arterioscler Thromb Vasc Biol. 2011, 31(6), 1377-86.
Comparison of different miR-21 inhibitor chemistries in a cardiac disease model
Thum T, Chau N, Bhat B, Gupta SK, Linsley PS, Bauersachs J & Engelhardt S.
J Clin Invest. 2011, 121(2), 461-2. Letter.
Altered synaptic plasticity and behavioral abnormalities in CNGA3-deficient mice
Michalakis S, Kleppisch T, Polta SA, Wotjak CT, Koch S, Rammes G, Matt L, Becirovic E & Biel M.
Genes Brain Behav. 2011, 10(2), 137-48.
Cyclic GMP kinase I modulates glucagon release from pancreatic α-cells
Leiss V, Friebe A, Welling A, Hofmann F & Lukowski R.
Diabetes. 2011, 60, 148-56.
HCN2 channels in local inhibitory interneurons constrain LTP in the hippocampal direct perforant path
Matt L, Michalakis S, Hofmann F, Hammelmann V, Ludwig A, Biel M & Kleppisch T.
Cell Mol Life Sci. 2011, 68, 125-37.
2010
Cyclic cytidine 3',5'-monophosphate (cCMP) signals via cGMP kinase I
Desch M, Schinner E, Kees F, Hofmann F, Seifert R & Schlossmann J.
FEBS Lett. 2010, 584, 3979-84.
Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome
Moretti A, Bellin M, Welling A, Jung CB, Lam JT, Bott-Flügel L, Dorn T, Goedel A, Höhnke C, Hofmann F, Seyfarth M, Sinnecker D, Schömig A & Laugwitz KL.
New Engl J Med. 2010, 363, 1397-409.
Early life environment determines the development of adult phobic-like fear responses in BALB/cAnN mice
Thoeringer CK, Pfeiffer UJ, Rammes G, Pamplona FA, Moosmang S & Wotjak CT.
Genes Brain Behav. 2010, 9, 947-57.
Electrical Activity Suppresses Axon Growth through Cav1.2 Channels in Adult Primary Sensory Neurons
Enes J, Langwieser N, Ruschel J, Carballosa-Gonzalez MM, Klug A, Traut MH, Ylera B, Tahirovic S, Hofmann F, Stein V, Moosmang S, Hentall ID & Bradke F.
Curr Biol. 2010, 20, 1154-1164.
Homeostatic Switch in Hebbian Plasticity and Fear Learning after Sustained Loss of Cav1.2 Calcium Channels
Langwieser N, Christel CJ, Kleppisch T, Hofmann F, Wotjak CT & Moosmang S.
J Neurosci. 2010, 30, 8367-8375.
Reply to Kass and Takimoto: Cardiac hypertrophy without cGKI and PDE5 in cardiac myocytes
Lukowski R, Rybalkin SD, Beavo JA & Hofmann F.
PNAS. 2010, 107, E99.
Facilitation of murine cardiac L-type Cav1.2 channel is modulated by Calmodulin kinase II–dependent phosphorylation of S1512 and S1570
Blaich A, Welling A, Fischer S, Wegener JW, Köstner K, Hofmann F & Moosmang S.
PNAS. 2010, 107, 10285-10289.
L-Type Calcium Channel CaV 1.2 in Transgenic Mice Overexpressing Human AbetaPP751 with the London (V717I) and Swedish (K670M/N671L) Mutations
Willis M, Kaufmann WA, Wietzorrek G, Hutter-Paier B, Moosmang S, Humpel C, Hofmann F, Windisch M, -Günther Knaus H & Marksteiner J.
J Alzheimers Dis. 2010, 20, 1167-1180.
A complex of CaV1.2/PKC is involved in muscarinic signaling in smooth muscle
Huster M, Frei E, Hofmann F & Wegener JW.
FASEB J. 2010, 24, 2651-9.
Genetic Ablation of L-Type Ca2+ Channels Abolishes Depolarization-Induced Ca2+ Release in Arterial Smooth Muscle
Fernández-Tenorio M, González-Rodríguez P, Porras C, Castellano A, Moosmang S, Hofmann F, Ureña J & López-Barneo J.
Circ Res. 2010, 106, 1285-1289.
Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes
Lukowski R, Rybalkin SD, Loga F, Leiss V, Beavo JA & Hofmann F.
PNAS 2010, 107, 5646-5651.
Ido brings down the pressure in systemic inflammation
Hofmann F
Nat Med. 2010, 16, 265-267.
cGMP-dependent protein kinase Type I promotes CREB/CRE-mediated gene expression in neurons of the lateral amygdala
Paul C, Stratil C, Hofmann F & Kleppisch T.
Neurosci Lett. 2010, 473, 82-86.
IRAG determines NO- and ANP-mediated smooth muscle relaxation
Desch M, Sigl K, Hieke B, Salb K, Kees F, Bernhard D, Jochim A, Spiessberger B, Höcherl K, Feil R, Feil S, Lukowski R, Wegener JW, Hofmann F & Schlossmann J.
Cardiovasc Res. 2010, 86, 496-505.
Moretti A, Bellin M, Jung CB, Thies TM, Takashima Y, Bernshausen A, Schiemann M, Fischer S, Moosmang S, Smith AG, Lam JT & Laugwitz KL.
FASEB J. 2010, 24, 700-711.
2009
Effects of cGMP-dependent protein kinase knockouts
Hofmann F & Kleppisch T.
Handb. Cell Signaling. 2009, 1515-1518.
Calcium-dependent and Calcium-independent inhibition of contraction by cGMP/cGKI in intestinal smooth muscle
Frei E, Huster M, Smital P, Schlossmann J, Hofmann F & Wegener JW.
Am J Physiol Gastrointest Liver Physiol. 2009, 297, G834-G839.
Combined Reporter Gene PET and Iron Oxide MRI for Monitoring Survival and Localization of Transplanted Cells in the Rat Heart
Higuchi T, Anton M, Dumler K, Seidl S, Pelisek J, Saraste A, Welling A, Hofmann F, Oostendorp RA, Gansbacher B, Nekolla SG, Bengel FM, Botnar RM & Schwaiger M.
J Nucl Med. 2009, 50, 1088-94.
Polymorphisms determine beta-adrenoceptor conformation: implications for cardiovascular disease and therapy
Ahles A & Engelhardt S.
Trends Pharmacol Sci. 2009, 30, 188-93.
Phospholipase C mediated Ca2+ signals in murine urinary bladder smooth muscle
Frei E, Hofmann F & Wegener JW.
Eur. J. Pharmacol. 2009, 610, 107-109.
GPCR and G proteins: drug efficacy and activation in live cells
Vilardaga JP, Buenemann M, Feinstein TN, Lambert N, Nikolaev VO, Engelhardt S, Lohse MJ & Hoffmann C.
Mol. Endocrinol. 2009, 23, 590-99.
cGMP-dependent protein kinase II and aldosterone secretion
Spiessberger B, Bernhard D, Herrmann S, Feil S, Werner C, Luppa PB & Hofmann F.
FEBS J. 2009, 276, 1007-13.
Analysis of receptor oligomerization by FRAP microscopy
Dorsch S, Klotz K-N, Engelhardt S, Lohse MJ & Bünemann M.
Nat. Methods. 2009, 6, 225-30.
Critical role of transcription factor cyclic AMP response element modulator in beta1-adrenoceptor-mediated cardiac dysfunction
Lewin G, Matus M, Basu A, Frebel K, Rohsbach SP, Safronenko A, Seidl MD, Stümpel F, Buchwalow I, König S, Engelhardt S, Lohse MJ, Schmitz W & Müller FU.
Circulation 2009, 119, 79-88.
cGMP Regulated Protein Kinases (cGK)
Hofmann F, Bernhard D, Lukowski R & Weinmeister P.
Handb. Exp. Pharmacol. 2009, 137-62.
Phosphodiesterases in the central nervous system
Kleppisch T.
Handb. Exp. Pharmacol. 2009, 71-92.
cGMP Signalling in the Mammalian Brain: Role in Synaptic Plasticity and Behaviour
Kleppisch T & Feil R.
Handb. Exp. Pharmacol. 2009, 549-79.
Voltage-dependent calcium channels
Welling A
BioTrend Rev. 2009, 4, 1-11
2008
Signaling through cGMP-dependent protein kinase I in the amygdala is critical for auditory-cued fear memory and long-term potentiation
Paul C, Schöberl F, Weinmeister P, Micale V, Wotjak CT, Hofmann F & Kleppisch T.
J. Neurosci. 2008, 28,14202-14212.
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
Thum T, Gross C, Fiedler J, Fischer T, Kissler S, Bussen M, Galuppo P, Just S, Rottbauer W, Frantz S, Castoldi M, Soutschek J, Koteliansky V, Rosenwald A, Basson MA, Licht JD, Pena JT, Rouhanifard SH, Muckenthaler MU, Tuschl T, Martin GR, Bauersachs J & Engelhardt S.
Nature 2008, 456, 980-984.
NO/cGMP-dependent modulation of synaptic transmission
Feil R & Kleppisch T.
Handb. Exp. Pharmacol. 2008, 184, 529 – 560.
Paradoxical resistance to myocardial ischemia and age-related cardiomyopathy in NHE1 transgenic mice: A role for ER stress?
Cook AR, Bardswell SC, Pretheshan S, Dighe K, Kanaganayagam GS, Jabr RI, Merkle S, Marber MS, Engelhardt S & Avkiran M.
J. Mol. Cell. Cardiol. 2009, 46, 225-233.
Cyclic guanosine monophosphate-dependent protein kinase I promotes adhesion of primary vascular smooth muscle cells
Weinmeister P, Lukowski R, Linder S, Traidl-Hoffmann C, Hengst L. Hofmann & Feil R.
Mol. Biol. Cell. 2008, 19, 4434 - 4441.
Unchanged ß-adrenergic stimulation of cardiac L-type calcium channels in Cav1.2 phosphorylation site S1928A mutant mice
Lemke T, Welling A, Christel CJ, Blaich A, Bernhard D, Lenhardt P, Hofmann F & Moosmang S.
Biol. Chem. 2008, 283, 34738-34744.
Tamoxifen-inducible gene deletion in the cardiac conduction system
Hoesl E, Stieber J, Herrmann S, Feil S, Tybl E, Hofmann F, Feil R & Ludwig A.
J. Mol. Cell. Cardiol. 2008, 45, 62 – 69.
Role of smooth muscle cGMP/cGKI signaling in murine vascular restenosis
Lukowski R, Weinmeister P, Bernhard D, Feil S, Gotthardt M, Herz J, Massberg S, Zernecke A, Weber C, Hofmann F & Feil R.
Arterioscler Thromb Vasc Biol. 2008 Jul; 28(7): 1244–1250.
Cav1.2 calcium channels modulate the spiking pattern of hippocampal pyramidal cells
Lacinova L, Moosmang S, Langwieser N, Hofmann F & Kleppisch T.
Life Sciences 2008, 82, 41 – 49.
Cysteine-rich protein 2, a novel downstream effector of cGMP/cGMP-dependent protein kinase I-mediated persistent inflammatory pain
Schmidtko A, Gao W, Sausbier M, Rauhmeier I, Sausbier U, Niederberger E, Scholich K, Huber A, Neuhuber W, Allescher HD, Hofmann F, Tegeder I, Ruth P & Geisslinger G.
J. Neurosci. 2008, 28, 1320 – 1330.
Phosphorylation of GSK-3b by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes
Kawasaki Y, Kugimiya F, Chikuda H, Kamekura S, Ikeda T, Kawamura N, Saito T, Shinoda Y, Higashikawa A, Yano F, Ogasawara T, Ogata N, Hoshi K, Hofmann F, Woodgett JR, Nakamura K, Chung U-il & Kawaguchi H.
J. Clin. Invest. 2008, 118, 2506 – 2515.
Anemia and splenomegaly in cGKI-deficient mice
Föller M, Feil S, Ghoreschi K, Koka S, Gerling A, Thunemann M, Hofmann F, Schuler B, Vogel J, Pichler B, Kasinathan RS, Nicolay JP, Huber,SM, Lang & Feil R.
PNAS 2008, 105, 6771-6776.
Tippens AL, Pare J-F, Langwieser N, Moosmang S, Milnewr TA, Smith Y & Lee A.
J. Comp. Neurol. 2008, 506, 569-83.
2007
Severe instestinal obstruction on induced smooth musle-specific ablation of the transcription factor SRF in adult mice
Angstenberger M, Wegener JW, Pichler BJ, Judenhofer MS, Feil S, Alberti S, Feil R & Nordheim A.
Gastroenterology 2007, 133, 1948 – 1959.
IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation
Antl M, von Brühl ML, Eiglsperger C, Werner M, Konrad I, Kocher T, Wilm M, Hofmann F, Massberg S & Schlossman J.
Blood 2007, 109, 552 – 559.
Antimalarial and vasorelaxant constituents of the leaves of Allanblackia monticola(Guttiferae)
Azebaze AGB, Dongmo AB, Meyer M, Ouahouo BMW, Valentin A, Nguemfo EL, Nkengfack AE & Vierling W.
Ann. Trop. Med. and Parasitol. 2007, 101, 23-30.
Döring B, Pfitzer G, Adam B, Liebregts T, Eckardt D, Holtmann G, Hofmann F, Feil S, Feil R & Willecke K.
Cell Tissue Res. 2007, 327, 333 – 342.
Vasodilator effect of the extracts and some coumarins from the stem bark of Mammea africana (Guttiferae)
Dongmo AB, Azebaze AGB, Nguelefack TB, Ouahouo BM, Sontia B, Meyer M, Nkengfack AE, Kamanyi A & Vierling W.
J. Ethnopharmacol. 2007, 111, 329 – 334.
Alternative signaling: cardiomyocyte beta1-adrenergic receptors signal through EGFRs
Engelhardt S.
J. Clin. Invest. 2007, 117, 2396-2398.
G proteins: more than transducers of receptor-generated signals?
Engelhardt S & Rochais F.
Circ. Res. 2007, 100, 1109- 1111.
Indirect coupling between Cav1.2 channels and ryanodine receptors to generate Ca 2+ sparks in murine arterial smooth muscle cells
Essin K, Welling A, Hofmann F, Luft FC, Gollasch M & Moosmang, S.
J. Physiol. 2007, 584, 205 – 219.
A secretion trap screen in yeast identifies protease inhibitor 16 as a novel antihypertrophic protein secreted from the heart
Frost RJ & Engelhardt S.
Circulation 2007, 116, 1768-1775.
Ca2+ channel currents and contraction in Ca-V beta (3)- deficient ileum smooth muscle from mouse
Held B, Tsvilovskyy V, Meissner M, Kaestner L, Ludwig A, Moosmang S, Lipp P, Freichel M & Flockerzi V.
Cell Calcium 2007, 42, 477-487.
HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice
Herrmann S, Stieber J, Stöckl G, Hofmann F & Ludwig A.
EMBO J. 2007, 26, 4423 – 4432.
A role for caspase-1 in heart failure
Merkle S, Frantz S, Schön MP, Bauersachs J, Buitrago M, Frost RJ, Schmitteckert EM, Lohse MJ & Engelhardt S.
Circ. Res. 2007, 100, 645-653.
Analysis of calcium channels by conditional mutagenesis
Moosmang S, Kleppisch T, Wegener J, Welling A & Hofmann F.
Handb. Exp. Pharmacol. 2007, 178, 469 – 490.
Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1 adrenergic receptor
Peter PS, Brady JE, Yan L, Chen W, Engelhardt S, Wang Y, Sadoshima J, Vatner SF, Vatner DE.
J. Clin. Invest. 2007, 117, 1335-1343.
Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol
Rochais F, Vilardaga JP, Nikolaev VO, Bünemann M, Lohse MJ & Engelhardt S.
J. Clin. Invest. 2007, 117, 29-235.
Activation of AP-1 Contributes to the beta-Adrenoceptor-Mediated Myocardial Induction of Interleukin-6
Rohrbach S, Engelhardt S, Lohse MJ, Werdan K, Holtz J & Muller-Werdan U.
Mol. Med. 2007, 13, 605-614.
Reduced rather than enhanced cholinergic airway constriction in mice with ablation of the large conductance Ca2+ - activated K+ channel
Sausbier M, Zhou XB, Beier C, Sausbier U, Wolpers D, Maget S, Martin C, Dietrich A, Ressmeyer AR, Renz H, Schlossmann J, Hofmann F, Neuhuber W, Gudermann T, Uhlig S, Korth M & Ruth P.
FASEB J. 2007, 21, 812 – 822.
The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord
Schmidt H, Stonkute A, Jüttner, R, Schäffer S, Buttgereit J, Feil R, Hofmann F & Rathjen FG.
J. Cell Biol. 2007, 179, 331 – 340.
Interstitial remodeling in beta1-adrenergic receptor transgenic mice
Seeland U, Selejan S, Engelhardt S, Müller P, Lohse MJ & Böhm M.
Basic Res. Cardiol. 2007, 102, 183-193.
MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure
Thum T, Galuppo P, Wolf C, Fiedler J, Kneitz S, van Laake LW, Doevendans PA, Mummery CL, Borlak J, Haverich A, Gross C, Engelhardt S, Ertl G & Bauersachs J.
Circulation 2007, 116, 258-267, 2. Erratum in: Circulation 116
Rescue of cGMP kinase I knockout mice by smooth muscle-specific expression of either isozyme
Weber S, Bernhard D, Lukowski R, Weinmeister P, Wörner R, Wegener JW, Valtcheva N, Feil S, Schlossmann J, Hofmann F & Feil R.
Circ. Res. 2007, 101, 1096 – 1103.
cGMP signals mainly through cAMP kinase in permeabilized murine aorta
Wörner R, Lukowski R, Hofmann F & Wegener JW.
Am. J. Phsyiol. Heart Circ. Physiol. 2007, 292, H237 – H244.
Goldstein PA. Dendritic HCN2 channels constrain glutamate-driven excitability in reticular thalamic neurons
Ying SW, Jia F, Abbas SY, Hofmann F, Ludwig A & Goldstein PA.
J. Neurosci. 2007, 27, 8719 – 8732.
2006
Antimalarial and vasorelaxant constituents of the leaves of Allanblackia monticola (Guttiferae)
Azebaze AGB, Dongmo AB, Meyer, M, Ouahouo BMW, Valentin A, Nguemfo EL, Nkengfack AE & Vierling W.
Ann. Trop. Med. and Parasitol. 2006, 100, 1 – 8.
Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated-caspase-3-independent cell death
Boesten LS, Zadelaar SM, de Clercq S, Francoz S, van Nieuwkoop A, Biessen EAL, Hofmann F, Feil S, Feil R, Jochemsen AG, Zurcher C, Havekes LM, van Vlijmen BJM & Marine JC.
Cell Death Differ. 2006, 13, 2089 – 2098.
A sensitive method for determining the phosphorylation status of natriuretic peptide receptors: cGK-I a does not regulate NPR-A
Bryan PM, Smirnov D, Smolenski A, Feil S, Feil R, Hofmann F, Lohmann S & Potter LR.
Biochem. 2006, 45, 1295 – 1303.
Ablation of connexin43 in uterine smooth muscle cells of the mouse causes delayed parturition
Döring B, Shynlova O, Tsui P, Eckardt D, Janssen-Bienhold U, Hofmann F, Feil S, Feil R, Lye SJ & Willecke K.
J. Cell Sciences 2006, 119, 1715 – 1722.
cGMP-dependent protein kinase Type I inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes
Fiedler B, Feil R, Hofmann F, Willenbockel C, Drexler H, Smolenski A, Lohmann SM & Wollert KC.
J. Biol. Chem. 2006, 281, 32831 – 32840.
The cGMP/protein kinase G pathway contributes to dihydropyridine-sensitive calcium response and cytokine production in TH2 lymphocytes
Gomes B, Savignac M, Cabral MD, Paulet P, Moreau M, Leclerc C, Feil R, Hofmann F, Guéry JC, Dietrich G & Pelletier L.
J. Biol. Chem. 2006, 281, 12421 - 12427.
Gs activation is time-limiting in initiating receptor-mediated signaling
Hein P, Rochais F, Hoffmann C, Dorsch S, Nikolaev VO, Engelhardt S, Berlot CH, Lohse MJ & Bünemann M.
J. Biol. Chem. 2006, 281, 33345-33351.
Function of cGMP-dependent protein kinases as revealed by gene deletion
Hofmann F, Feil R, Kleppisch T & Schlossmann J.
Physiol. Rev. 2006, 86, 1 – 23.
Gating of the expressed T-type Cav3.1 calcium channels is modulated by Ca2+
Lacinova L, Kurejova M, Klugbauer N & Hofmann F.
Acta Physiol. 2006, 186, 249 – 260.
Calmodulin kinase II is involved in voltage-dependent facilitation of the L-type Cav1.2 calcium channel
Lee TS, Karl R, Moosmang S, Lenhardt P, Klugbauer N, Hofmann F, Kleppisch T & Welling A.
J. Biol. Chem. 2006, 281, 25560-25567.
Antihypertensive effects of the putative T-type calcium channel antagonist mibefradil are mediated by the L-type calcium channel Cav1.2
Moosmang S, Haider N, Brüderl B, Welling A & Hofmann F.
Circ. Res. 2006, 98, 105 – 110.
Membrane resting potential of thalamocortical relay neurons is shaped by the interaction among TASK3 and HCN2 channels
Meuth SG, Kanyshkova T, Meuth P, Landgraf P, Munsch T, Ludwig A, Hofmann F, Pape HC & Budde, T.
J. Neurophysiol. 2006, 96, 1517 – 1529.
Spasmolytic effects of extracts from Kalanchoe crenataandrews (Crassulaceae) leaves
Nguelefack TB, Sontia B, Dongmo AB, Dimo T, Kamanyi A & Vierling W.
Pharmacologyonline 2006, 1, 30 – 39.
Bradycardic and proarrhythmic properties of sinus node inhibitors
Stieber J, Wieland K, Stöckl G, Ludwig A & Hofmann F.
Mol. Pharmacol. 2006, 69, 1328 – 1337.
Besonderheiten der Arnzeimittelanwendung im Alter
Vierling W.
In Medizin des Alterns und des alten Menschen 2006, Hrsg. Werner Hansen, Schattauer Verlag Stuttgart, 94 – 115.
Characterization of voltage-dependent sodium and calcium channels in mouse pancreatic A- and B-cells
Vignali S, Leiss V, Karl R, Hofmann F & Welling A.
J. Physiol. 2006, 527, 691 – 706.
Control of intestinal motility by the Cav1.2 L-type calcium channel in mice
Wegener J, Schulla V, Koller A, Klugbauer N, Feil R & Hofmann F.
FASEB J. 2006, 20, 1260 – 1262.
2005
Activation of CFTR by ASBT-mediated bile salt absorption
Bijvelds MJ, Jorna H, Verkade HJ, Bot AG, Hofmann F, Agellon LB, Sinaasappel M & de Jonge JR.
Am. J. Physiol. Gastrointest. Liver Physiol. 2005, 289, G870 – G879.
The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy
Buitrago M, Lorenz K, Maass AH, Oberdorf-Maass S, Keller U, Schmitteckert EM, Ivashchenko Y, Lohse MJ & Engelhardt S.
Nat. Med. 2005, 11, 837-844.
Impaired neocortical organization in mice lacking cGMP-dependent protein kinase I
Demyanenko GP, Halberstadt AI, Pryzwansky KB, Werner C, Hofmann F & Maness PF.
Brain Res. Dev. Brain Res. 2005, 160, 1 – 8.
Beta-adrenergic receptors in heart failure
Engelhardt S.
Heart Fail Clin. 2005, 1, 183-191 Review.
A heretical view on the role of NO and cGMP in vascular proliferative diseases
Feil R, Feil S & Hofmann F.
Trends in Molecular Medicine 2005, 111, 71 – 75.
Function of cGMP-dependent protein kinases in the nervous system
Feil R, Hofmann F & Kleppisch T.
Rev. Neurosci. 2005, 16, 23 – 41.
Distribution of cGMP-dependent protein kinase Type I and its isoforms in the mouse brain and retina
Feil S, Zimmermann P, Knorn A, Brummer S, Schlossmann J, Hofmann F & Feil R.
Neurosci. 2005, 135, 863 – 868.
Self-limitation of intravenous tocolysis with beta2-adrenergic agonists is mediated through receptor G protein uncoupling
Frambach T, Müller T, Freund S, Engelhardt S, Sütterlin M, Lohse MJ & Dietl J.
J. Clin. Endocrino.l Metab. 2005, 90, 2882-2887.
Schrittmacherkanäle: Wächter an Hirn und Herz
Herrmann S, Stieber J, Ludwig A & Hofmann F.
Jahrbuch 2004 der Deutschen Akademie der Naturforscher Leopoldina (Halle/Saale) 2005, 50, 421 – 428.
The biology of cyclic GMP-dependent protein kinases
Hofmann F.
J. Biol. Chem. 2005, 280, 1 – 4.
International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels
Hofmann F, Biel M & Kaupp B.
Pharmacol. Rev. 2005, 57, 455 – 462.
Ca2+ -and voltage-dependent inactivation of the expressed L-type Cav1.2 calcium channel
Lacinova L & Hofmann F.
Arch. of Biochemistr. and Biophys. 2005, 437, 42 – 50.
Cre/loxP-vermittelte konditionale Mutagenese des cGMP-Signalwegs in der Maus
Lukowski R, Weber S, Weinmeister P, Feil S & Feil R
Biospektrum 2005, 3, 287 – 290.
Impaired opsin targeting and cone photoreceptor migration in the retina of mice lacking the cyclic nucleotide-gated channel CNGA3
Michalakis S, Geiger H, Haverkamp S, Hofmann F, Gerstner A & Biel M.
Invest. Ophthalmol. & Visual Science 2005, 46, 1516 – 1524.
Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory
Moosmang S, Haider N, Klugbauer N, Adelsberger H, Langwieser N, Müller J, Stiess M, Marais E, Schulla V, Lacinova L, Goebbels S, Nave KA, Storm DR, Hofmann F & Kleppisch T.
J. Neurosci. 2005, 25, 9883 – 9892.
Mouse models to study L-type calcium channel function
Moosmang S, Lenhardt P, Haider N, Hofmann F & Wegener JW.
Pharmacol. & Therap. 2005, 106, 347 – 355.
Real-time monitoring of the PDE2 activity of live cells: hormone-stimulated cAMP hydrolysis is faster than hormone-stimulated cAMP synthesis
Nikolaev VO, Gambaryan S, Engelhardt S, Walter U & Lohse MJ.
J. Biol. Chem. 2005, 280, 1716-1719.
Insights into cGMP signalling derived from cGMP kinase knockout mice
Schlossmann J, Feil R & Hofmann F.
Frontiers in Bioscience 2005, 10, 1279 – 1289.
Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice
Sausbier M, Arntz C, Bucurenciu I, Zhao H, Zhou XB, Sausbier U, Feil S, Kamm S, Essin K, Sailer CA, Adullah U, Krippeit-Drews P, Feil R, Hofmann F, Knaus HG, Kenyon C, Shipston MJ, Storm JF, Neuhuber W, Korth M, Schubert R, Gollasch M & Ruth P.
Circ. 2005, 112, 60 – 68.
cGMP-dependent protein kinases in drug disvovery
Schlossmann J & Hofmann F.
DDT 2005, 10, 627 – 634.
Bedeutung des Schrittmacherkanals HCN4 im embryonalen Herzen der Maus
Stieber J.
Biospektrum 2005, 2, 213 – 214.
Functional expression of the human HCN3 channel
Stieber J, Stöckl G, Herrmann S, Hassfurth B & Hofmann F.
J. Biol. Chem. 2005, 280, 34635 – 34643.
Effects of polyphenols and magnesium on functions of heart and vascular smooth muscle: similarities and differences
Vierling W, Sontia B, Müller B & Wagner H.
In Biopolyphenol und Magnesium – Südsteirische Schätze, eds S. Porta and D. Gualtieri, 1st edition 2005, 104 – 116 (Edition B, Graz, Österreich).
25th Magnesium-Symposium of the Society of Magnesium Research, 8.-9. Okt. 2004 in München
Vierling W.
J. Trace Elem. Electrolytes Health Dis. 2005, 22, 160 – 168.
Inhibition of L-type Cav1.2 Ca2+ -channels by 2,(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) and 2-[1-(3-Dimethylaminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide (Gö6983)
Welling A, Hofmann F & Wegener JW.
Mol. Pharmacol. 2005, 67, 541 – 544.
Neutrophil dysfunction in guanosine 3`,5`-cyclic monophosphate-dependent protein kinase I-deficient mice
Werner CG, Godfrey V, Arnold RR, Featherstone GL, Bender D, Schlossmann J, Schiemann M, Hofmann F & Pryzwansky KB.
J. Immunol. 2005, 175, 1919 –1929.
2004
Cyclic Nucleotide-Regulated Cation Channels
Biel M & Hofmann F.
In Encyclopedia of Biological Chemistry, eds. Lennarz, W. u. Lane, M.D., Elsevier Science (USA) 2004, Volume 1, 512-515.
Entla, a novel epileptic and ataxic Cacna2d2 mutant of the mouse
Brill J, Klocke R, Paul D, Boison D, Gouder N, Klugbauer N, Hofmann F, Becker CM & Becker K.
J. Biol. Chem. 2004, 279, 7322 – 7330.
Vasodilating properties of the stem bark extract of Mitragyna ciliata in rats and guinea pigs
Dongmo A, Kamanyi MA, Tan PV, Bopelet M, Vierling W & Wagner H.
Phytother. Res. 2004, 18, 36 – 39.
Altered calcium handling is critically involved in the cardiotoxic effects of chronic beta-adrenergic stimulation
Engelhardt S, Hein L, Dyachenkow V, Kranias EG, Isenberg G & Lohse MJ.
Circulation 2004, 109, 1154-1160.
SM22a Modulates vascular smooth muscle cell phenotype during atherogenesis
Feil S, Hofmann F & Feil R.
Circ. Res. 2004, 94, 863 – 865.
Calcium channel function and regulation in beta 1- and beta 2-adrenoceptor transgenic mice
Foerster K, Kaeferstein T, Groner F, Engelhardt S, Matthes J, Koch WJ, Lohse MJ & Herzig S.
Naunyn Schmiedebergs Arch. Pharmacol. 2004, 369, 490-5.
InsP3R-associated cGMP kinase substrate (IRAG) is essential for nitric oxide-induced inhibition of calcium signaling in human colonic smooth muscle
Fritsch R, Saur D, Kurjak M, Oesterle D, Schlossmann J, Geiselhöringer A, Hofmann F & Allescher HD.
J. Biol. Chem. 2004, 279, 12551-12559.
Distribution of IRAG and cGKI-isoforms in murine tissues
Geiselhöringer A, Gaisa M, Hofmann F & Schlossmann J.
FEBS Lett. 2004, 575, 19 – 22.
IRAG is essential for relaxation of receptor-triggered smooth musle contraction by cGMP kinase
Geiselhöringer A, Werner M, Sigl K, Smital P, Wörner R, Acheo L, Stieber J, Weinmeister P, Feil R, Feil S, Wegener J, Hofmann F & Schlossmann J.
EMBO J. 2004, 23, 4222-4231.
Wirkungen von Pharmaka auf den Organismus: allgemeine Pharmakodynamik
Hofmann F.
In Allgemeine und spezielle Pharmakologie und Toxikologie, Eds. Aktories, Förstermann, Hofmann, Starke, 9. Auflage 2004, Urban & Fischer – Verlag, 5 – 25.
Wächter am Herz und Bewußtsein – Schrittmacherkanäle (Pacemaker Channels and the Control of Heart Rhythm and Awarness
Hofmann F.
Sitzungsberichte der Bayerischen Akademie der Wissenschaften, Jahrgang 2001 – 2003, Verlag C.H. Beck 2004, München, 16 – 17.
Mouse Models of NO/Natriuretic Peptide/cGMP Kinase Signaling
Hofmann F, Biel M, Feil R & Kleppisch T.
In Transgenic Models in Pharmacology, Eds. Stefan Offermanns u. Lutz Hein, Handbook of Experimental Pharmacology, Springer – Verlag 2004, Vol.159, 95 –130.
Molecular basis of pacemaking
Hofmann F & Stieber J.
In Rezeptoren – Mediatoren, Ihre Rolle bei modernen Therapieansätzen, Eds. Michel und Wolf, Schattauer Verlag 2004, 71 – 81.
cGMP-dependent protein kinase mediates NO- but not ACh-induced dilations in resistance vessels in vivo
Koeppen M, Feil R, Siegl D, Feil S, Hofmann F, Pohl U & de Wit C.
Hypertension 2004, 44, 952 – 955.
HCN Channels: From genes to function
Ludwig A, Stieber J, Moosmang S, Herrmann S, Biel M & Hofmann F.
In „Cardiac Electrophysiology“ From Cell to Bedside, Eds. Zipes & Jalife, 4th Ed. 2004, Saunders, 59 – 65.
Marshall SJ, Senis YA, Auger JM, Feil R, Hofmann F, Salmon G, Perterson,JT, Burslem F & Watson SP.
Blood 2004, 103, 2601 – 2609.
Pulmonary hypertension and right heart failure in pituitary adenylate cyclase-activating polypeptide type I receptor-deficient mice
Otto C, Hein L, Brede M, Jahns R, Engelhardt S, Gröne HJ & Schütz G.
Circulation 2004, 110, 3245-3251.
Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency
Sausbier M, Hu H, Arntz C, Feil S, Kamm S, Adelsberger H, Sausbier U, Sailer CA, Feil R, Hofmann F, Korth M, Shipston MJ, Knaus HG, Wolfer DP, Pedroarena CM, Storm JF & Ruth P.
PNAS 2004, 101, 9474 – 9478.
Current status of drug receptor nomenclature: receptor closure? The role of NC-IUPHAR
Spedding M, Foord SM & Hofmann F.
Expert Opin. Investig. Drugs 2004, 13, 461 – 464.
Pacemaker channels and sinus node arrthythmia
Stieber J, Hofmann F & Ludwig A.
Trends Cardiovas. Med. 2004, 14, 23 – 28.
Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I
Tegeder I, Del Turco D, Schmidtko A, Sausbier M, Feil R, Hofmann F, Deller T, Ruth P. & Geisslinger G.
PNAS 2004, 101, 3253 – 3257.
Institut für Pharmakologie und Toxikologie, Fakultät für Medizin der Technischen Universität München
Vierling W.
In: Geschichte und Wirken der pharmakologischen, klinisch – pharmakologischen und toxikologischen Institute im deutschsprachigen Raum, Ed. A. Philippu, Beerenkamp Verlag Innsbruck 2004, 542 – 546.
An essential role of Cav1.2 L-type calcium channel for urinary bladder function
Wegener JW, Schulla V, Lee TS, Koller A, Feil S, Feil R, Kleppisch T, Klugbauer N, Moosmang S, Welling A & Hofmann F.
FASEB J. 2004, 18, 1159 – 1161.
Importance of NO/cGMP signaling via cGMP-dependent protein kinase II for controlling emotionality and neurobehavioural effects of alcohol
Werner C, Raivich G, Cowen M, Stekalowa T, Sillaber I. Buters JT, Spanagel R & Hofmann F.
Eur. J. Neurosci. 2004, 20, 3498 – 3506.
Circadian and short-term regulation of blood pressure and heart rate in transgenic mice with cardiac overexpression of the beta1-adrenoceptor
Witte K, Engelhardt S, Janssen BJ, Lohse M & Lemmer B.
Chronobiol. Int. 2004, 21, 205-216.
Proteomics strategies in cardiovascular research
Zerkowski HR, Grussenmeyer T, Matt P, Grapow M, Engelhardt S & Lefkovits I.
J. Proteome Res. 2004, 3, 200-208 Review.
2003
Vasodilating effect of the root bank extract of Ficus saussureana on guinea pig aorta
Dongmo AB, Ndom JC, Massoma LD, Dzikouk DG, Fomani M, Kamanyi A & Vierling W.
Pharm. Biol. 2003, 41, 371 – 374.
Disruption of cardiac Ena-VASP protein localization in intercalated disks causes dilated cardiomyopathy
Eigenthaler M, Engelhardt S, Schinke B, Kobsar A, Schmitteckert E, Gambaryan S, Engelhardt CM, Krenn V, Eliava M, Jarchau T, Lohse MJ, Walter U & Hein L.
Am. J. Physiol. Heart Circ. Physiol. 2003, 285, H2471-H2481.
Dominant-negative suppression of HCN channels markedly reduces the native pacemaker current If and undermines spontaneous beating of neonatal cardiomyocytes
Er F, Larbig R, Ludwig A, Biel M, Hofmann F, Beuckelmann DJ & Hoppe UC.
Circulation 2003, 107, 485 – 489.
Impairment of LTD and cerebellar learning by Purkinje cell-specific ablation of cGMP-dependent protein kinase I
Feil R, Hartmann J, Luo C, Wolfsgruber W, Schilling K, Feil S, Barski JJ, Meyer M, Konnerth A, de Zeeuw CI & Hofmann F.
J. Cell Biology 2003, 163, 295 – 302.
Cyclic GMP-dependent protein kinases and the cardiovascular system: Insights from genetically modified mice
Feil R, Lohmann SM, de Jonge H, Walter U & Hofmann F.
Circ Res. 2003, 93, 907 – 916.
Common genomic response in different mouse models of beta-adrenergic-induced cardiomyopathy
Gaussin V, Tomlinson JE, Depre C, Engelhardt S, Antos CL, Takagi G, Hein L, Topper JN, Liggett SB, Olson EN, Lohse MJ, Vatner SF & Vatner DE.
Circulation 2003, 108, 2926-2933.
Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice
Hattar S, Lucas RJ, Mrosovsky N, Thompson S, Douglas RH, Hankins MW, Lem J, Biel M, Hofmann F, Foster RG & Yau KW.
Nature 2003, 424, 76 – 81.
Smooth muscle tone regulation
Hofmann F.
In: Encyclopedic Reference of Molecular Pharmacology, Eds. Stefan Offermanns u. Walter Rosenthal, Springer Verlag 2003, 870 – 875.
Voltage-dependent Ca2+ - channels
Hofmann F.
In: Encyclopedic Reference of Molecular Pharmacology, Eds. Stefan Offermanns u. Walter Rosenthal, Springer Verlag 2003, 994 - 999.
International Union of Pharmacology XLII. Compendium of voltage-gated ion channels: cyclic nucleotide-modulated channels
Hofmann F, Biel M & Kaupp B.
Pharmacol. Rev. 2003, 55, 587 – 589.
Effects of cGMP – dependent protein kinase knockouts
Hofmann F, Feil R, Kleppisch T & Werner C.
Handbook of Cell Signaling, ed. R. Bradshaw and E. Dennis, Academic Press 2003, Vol. 2 , 511 – 514.
Endothelium mediated aortic relaxation and blood pressure lowering effect of a procyanidin rich fraction of the stembark extracts of Erythrophleum suaveolens
Kamanyi A, Dongmo AB, Salah MA, Jatsa H, Wagner H, Vierling W & Bopelet M.
Pharm. Biol. 2003, 41, 62 – 67.
Hippocampal cGMP-dependent protein kinase I supports an age- and protein synthesis-dependent component of long-term potentiation but is not essential for spatial reference and contextual memory
Kleppisch T, Wolfsgruber W, Feil S, Allmann R, Wotjak C, Goebbels S, Nave KA, Hofmann F & Feil R.
J. Neurosci. 2003, 23, 6005 – 6012.
Calcium channel a2d subunits: Differential expression, function and drug binding
Klugbauer N, Marais E & Hofmann F.
J. Bioenerg. and Biomembr. 2003, 35, 639 – 647.
Association of phospholamban with a cGMP kinase signaling complex
Koller A, Schlossmann J, Ashman K, Uttenweiler-Joseph S, Ruth P & Hofmann F.
Biochem. Biophys. Res. Comm. 2003, 300, 155 – 160.
A stimulatory role for cGMP-dependent protein kinase in platelet activation
Li Z, Xi X, Gu M, Feil R, Ye R, Eigenthaler M, Hofmann F & Du X.
Cell 2003, 112, 77 – 86.
What is the role of beta-adrenergic signaling in heart failure?
Lohse MJ, Engelhardt S & Eschenhagen T.
Circ. Res. 2003, 93, 896-906 Review.
Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2
Ludwig A, Budde T, Stieber J, Moosmang S, Wahl C, Holthof, K, Langebartels A, Wotjak C, Munsch T, Zong X, Feil S, Feil R, Lancel M, Chien KR, Konnerth A, Pape HC, Biel M & Hofmann F.
EMBO J. 2003, 22, 216 – 224.
Partial agonist activity of bucindolol is dependent on the activation state of the human beta1-adrenergic receptor
Maack C, Böhm M, Vlaskin L, Dabew E, Lorenz K, Schäfers HJ, Lohse MJ & Engelhardt S.
Circulation 2003, 108, 348-353.
Laboratory acquired infection with recombinant vaccinia virus containing an immunomodulating construct
Mempel M, Isa G, Klugbauer, N, Meyer H, Wildi G, Ring J, Hofmann F & Hofmann H.
J. Invest. Dermatol. 2003, 120, 356 – 358.
Dominant role of smooth muscle L-type calcium channel Cav 1.2 role blood pressure regulation
Moosmang S, Schulla V, Welling A, Feil R, Feil S, Wegener JW, Hofmann F & Klugbauer N.
EMBO J. 2003, 22, 6027 – 6034.
Direct activation of PDE5 by cGMP: long-term effects within NO/cGMP signaling
Mullershausen F, Friebe A, Feil R, Thompson WJ, Hofmann F & Koesling D.
J. Cell. Biol. 2003, 160, 719 – 727.
Physiology and Pathophysiology of vascular signaling controlled by cyclic guanosine 3´,5´-cyclic monophosphate-dependent protein kinase
Münzel T, Feil R, Mülsch A, Lohmann SM, Hofmann F & Walter U.
Circulation 2003, 108, 2172 – 2183.
cGMP-dependent protein kinase II modulates mPer1 and mPer2 gene induction and influences phase shifts of the circadian clock
Oster H, Werner C, Magnone MC, Mayser H, Feil R, Seeliger MW, Hofmann F & Albrecht U.
Curr. Biol. 2003, 13, 725 – 733.
Signaling through NO and cGMP-dependent protein kinases
Schlossmann J, Feil R & Hofmann F.
Ann. Med. 2003, 35, 21 – 27.
Impaired insulin secretion and glucose tolerance in β cell-selective Cav1.2 Ca2+-channel null mice
Schulla V, Renström E, Feil R, Feil S, Franklin I, Gjinovci A, Jing XJ, Laux D, Lundquist I, Magnuson MA, Obermüller S, Olofsson CS, Salehi A, Wendt A, Klugbauer N, Wollheim CB, Rorsman P & Hofmann F.
EMBO J. 2003, 22, 3844 – 3854.
Individual cerebellar Purkinje cells express different cGMP phosphodiesterases (PDEs): In Vivo phosphorylation of cGMP-specific PDE (PDE5) as an indicator of cGMP-dependent protein kinase (PKG) activation
Shimizu-Albergine M, Rybalkin SD, Rybalkina IG, Feil R, Wolfsgruber W, Hofmann F & Beavo JA.
J. Neurosci. 2003, 23, 6452 – 6459.
The hyperpolariation-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart
Stieber J, Herrmann S, Feil S, Löster J, Feil R, Biel M, Hofmann F & Ludwig A.
PNAS 2003, 100, 15235 – 15240.
Alterations in the myocardial creatine kinase system precede the development of contractile dysfunction in beta(1)-adrenergic receptor transgenic mice
Spindler M, Engelhardt S, Niebler R, Wagner H, Hein L, Lohse MJ & Neubauer S.
J. Mol. Cell. Cardiol. 2003, 35, 389-397.
Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4
Stieber J, Thomer A, Much B, Schneider A, Biel M & Hofmann F.
J. Biol. Chem. 2003, 278, 33672 – 33680.
Pore structure influences gating properties of the T-type Ca2+ channel a1G
Talavera K, Janssens A, Klugbauer N, Droogmans G & Nilius B.
J. Gen. Physiol. 2003, 121, 529 – 540.
Talavera K, Janssens A, Klugbauer N, Droogmans G & Nilius B.
J. Gen. Physiol. 2003, 121, 511 – 528.
Autophosphorylation of cGMP-dependent Protein Kinase Type II
Vaandrager AB, Hogema BM, Edixhoven M, van den Burg CMM, Bot AGM, Klatt P, Ruth P, Hofmann F, van Damme J, Vandekerckhove J & de Jonge HR.
J. Biol. Chem. 2003, 278, 28651 – 28658.
Investigation of the pharmaceutical and pharmacological equivalence of different Hawthorn extracts
Vierling W, Brand N, Gaedcke F, Sensch KH, Schneider E & Scholz M.
Phytomedicine 2003, 10, 8 – 16.
Voltage-dependent effects of barnidipine in rat vascular smooth muscle
Wegener JW, Korstanje C & Nawrath H.
J. Cardiovasc. Pharmacol. 2003, 42, 218 – 223.
Hypothyroidism does not affect the dihydropyridine sensitivity of precontracted murine uterus
Wegener JW, Lee M & Hofmann F.
Can. J. Physiol. Pharmacol. 2003, 81, 890 – 893.
A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cells
Wolfsgruber W, Feil S, Brummer S, Kuppinger O, Hofmann F & Feil R.
PNAS 2003, 100, 13519 – 13524.
Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice
Xu M, Welling A, Paparisto S, Hofmann F & Klugbauer N.
J. Biol. Chem. 2003, 278, 40837 – 40841.